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KMID : 0352720140380040244
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Journal of Ginseng Research
2014 Volume.38 No. 4 p.244 ~ p.250
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Rg3-enriched Korean Red Ginseng improves vascular function in spontaneously hypertensive rats
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Park Jung-Bum
Kwon Sun-Kwan
Harsha Nagar
Jung Saet-byel
Jeon Byeong-Hwa
Kim Chang-Sup
Oh Jin-Hwan
Song Hee-Jung
Kim Cuk-Seong
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Abstract
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Background: Panax ginseng has distinct and impressive health benefits, such as improved blood pressure and immune system functioning. Rg3-enriched Korean Red Ginseng (REKRG) isolated from Korean Red Ginseng contains a high percentage of Rg3. Methods: In this study, we examined the effects of REKRG on endothelial cell nitric oxide synthase (eNOS) activation and adhesion molecules in endothelial cells and vascular function in rats. Results: REKRG dose-dependently increased eNOS phosphorylation and nitric oxide (NO) production in endothelial cells. In addition, REKRG markedly inhibited the tumor necrosis factor-α (TNF-α)-mediated induction of intercellular adhesion molecule (ICAM)-1 and cyclooxygenase (COX)-2 expressions in endothelial cells. REKRG improved endothelium-dependent vasorelaxation in the Wistar-Kyoto (WKY) rat and spontaneously hypertensive rats (SHRs) compared with controls. Furthermore, REKRG treatment for 6 weeks increased serum NO levels and reduced the mean aortic intima-media thickness compared with controls. Conclusion: Taken together, these results suggest that REKRG increased vascular function and improved immune system functioning. Therefore, REKRG is a very useful food for preventing or improving various cardiovascular diseases.
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KEYWORD
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eNOS, NO, Panax ginseng, REKRG, SHR
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